The activities in the Digital Health domain at GATE leverage our researchers’ expertise in developing and deploying Artificial Intelligence, Machine Learning, biostatistics and bioinformatics methods to biomedical problems, especially those, related to cognitive diseases. Our main focus is on the Alzheimer’s disease (AD), a highly heterogeneous disease with diverse clinical manifestations and rate of progression that affects millions of people worldwide. Its causes are mostly unknown and currently it is not possible to reverse the cognitive decline, although a new medication was recently approved.