30 million people across Europe are affected approximately by rare diseases. Brain disorders (including, but not limited to those affecting mental health) remain a major challenge. The understanding of mental disorders’ determinants and causes, processes and impacts is a key to their prevention, early detection and treatment as well as factor for good health and well-being. In order to improve health and disease understanding, a close linkage between fundamental, clinical, epidemiological and socio-economic research is required. Effective sharing of data, standardized data processing and the linkage of such data with large-scale cohort studies is a prerequisite for translation of research findings into the clinic. In this context, this paper proposes a platform for the exploration of behavioural changes in patients with proven cognitive disorders with a focus on Multiple Sclerosis. It adopts the concept of a digital twin by applying Big Data and Artificial Intelligence technologies to allow for deep analysis of medical data to estimate human health status, accurate diagnosis and adequate treatment of patients. The platform has two main components. The first component provides functionality for diagnostics and rehabilitation of Multiple Sclerosis and acts as the main provider of data for the second component. The second component is an advanced analytical application, which provides services for data aggregation, enrichment, analysis and visualization that will be used to produce new knowledge and support decision in each instance of the transactional component.