Preserving the complex structures of our cultural heritage buildings is a primary commitment, as they embody the cornerstone of our history and our common identity. The impact of weather conditions on these buildings is particularly evident.  To mitigate the impact of climatic phenomena, innovative solutions utilising advanced technological methods are imperative. This paper proposes a new approach to this complex preservation challenge without compromising historical integrity. This methodology aims to predict wind behaviour and delineate distinct risk exposure zones within cultural buildings and structures using computational fluid dynamics (CFD) models. A case study on the Byzantine-era castle of Mytilene, Greece illustrates the practical application of this approach along with insights crucial for targeted conservation strategies.  In conclusion, the final section highlights the effectiveness of the proposed methodology, offering prospects for future research and practical applications in heritage conservation.